Risk of heart disease often runs in families, suggesting a genetic influence. Genetic testing allows us to look at your DNA to identify any differences that could predispose you to developing certain health problems. In some cases genetic testing may be used to diagnose an inherited cardiac disease. However, in most cases genetic testing is used to help determine which family members could develop the heart problems that are running in the family and which family members will not develop those heart problems. Those identified at risk of heart disease could change their lifestyle and take therapeutic measures to reduce their risk of developing the disease.
Pan-Cardio NGS Panel
223 Genes:
A2ML1, ABCC9, ACTA2, ACTB, ACTC1, ACTN2, ACVR2B, ACVRL1, AKAP9, ALMS1, ANK2, ANKRD1, APOA5, APOB, BAG3, BBS10, BCOR, BMPR2, BRAF, CACNA1C, CACNA2D1, CACNB2, CALM1, CALM2, CALM3, CALR3, CASQ2, CAV1, CAV3, CBL, CBS, CCDC103, CCDC39, CCDC40, CHD7, CHRM2, COL3A1, COL5A1, COL5A2, COX15, CPT1A, CRELD1, CRYAB, CSRP3, CTF1, CTNNA3, DES, DMD, DNAAF1, DNAAF2, DNAAF3, DNAAF5, DNAH11, DNAH5, DNAI1, DNAI2, DNAL1, DOLK, DSC2, DSG2, DSP, DTNA, DYX1C1, ELAC2, ELN, EMD, ENG, EYA4, FBN1, FBN2, FHL1, FHL2, FKRP, FKTN, FLNA, FOXH1, FXN, GAA, GATA4, GATA6, GATAD1, GDF1, GJA1, GJA5, GLA, GPC3, GPD1L, GYG1, HAMP, HAND1, HCN4, HFE, HFE2, HRAS, ILK, INVS, JAG1, JPH2, JUP, KAT6B, KCNA5, KCND3, KCNE1, KCNE2, KCNE3, KCNE5, KCNH2, KCNJ2, KCNJ5, KCNJ8, KCNK3, KCNQ1, KRAS, LAMA4, LAMP2, LDB3, LDLR, LDLRAP1, LEFTY2, LMNA, LZTR1, MAP2K1, MAP2K2, MED12, MED13L, MIB1, MKS1, MRPL3, MTO1, MURC, MYBPC3, MYH11, MYH6, MYH7, MYL2, MYL3, MYLK, MYLK2, MYOM1, MYOZ2, MYPN, NDUFAF1, NEBL, NEK8, NEXN, NF1, NKX2-5, NKX2-6, NME8, NODAL, NOTCH1, NPHP3, NPPA, NR2F2, NRAS, NSD1, OFD1, PCSK9, PDLIM3, PKP2, PLN, PLOD1, PRDM16, PRKAG2, PRKG1, PSEN2, PTPN11, RAF1, RANGRF, RASA1, RBM20, RIT1, RRAS, RYR2, SCN10A, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SDHA, SGCD, SHOC2, SKI, SLC25A20, SLC2A10, SLC40A1, SLMAP, SMAD3, SMAD4, SMAD6, SMAD9, SNTA1, SOS1, SOS2, SPRED1, SYNE1, TAZ, TBX1, TBX20, TBX5, TCAP, TFR2, TGFB2, TGFB3, TGFBR1, TGFBR2, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TRDN, TRPM4, TTC8, TTN, TTR, TXNRD2, VCL, YWHAE, ZFPM2, ZIC3
Alagille Syndrome NGS Panel
02 Genes:
JAG1, NOTCH2
Arrhythmia NGS Panel
45 Genes:
AKAP9, ANK2, CACNA1C, CACNA2D1, CACNB2, CALM1, CASQ2, CAV3, CPT1A, DES, DSC2, DSG2, DSP, GJA5, GPD1L, GYG1, HCN4, JUP, KCNA5, KCND3, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ8, KCNQ1, LDB3, LMNA, NKX2-5, NPPA, PKP2, PRKAG2, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SLC25A20, SNTA1, TBX5, TGFB3, TMEM43, TRDN, TRPM4
Arrhythmogenic Right Ventricular Cardiomyopathy NGS Panel
34 Genes:
AKAP9, ANK2, CACNA1C, CACNB2, CASQ2, CAV3, DES, DSC2, DSG2, DSP, GPD1L, HCN4, JUP, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, KCNJ8, KCNQ1, LDB3, LMNA, NKX2-5, PKP2, RANGRF, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SNTA1, TGFB3, TMEM43
Atrial Fibrillation NGS Panel
24Genes:
ABCC9, GATA4, GATA6, GJA5, HCN4, KCNA5, KCND3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNJ5, KCNJ8, KCNQ1, LDB3, LMNA, NPPA, NUP155, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A
15 Genes:
CACNA1C, CACNA2D1, CACNB2, GPD1L, HCN4, KCND3, KCNE3, KCNE5, KCNJ8, RANGRF, SCN1B, SCN2B, SCN3B, SCN5A, TRPM4
Cardio-Facio-Cutaneous Syndrome NGS Panel
06 Genes:
BRAF, KRAS, MAP2K1, MAP2K2, SHOC2, SOS1
Catecholaminergic Polymorphic Ventricular Tachycardia NGS Panel
09 Genes:
ANK2, CALM1, CALM2, CALM3, CASQ2, KCNJ2, KCNQ1, RYR2, TRDN
Congenital Heart Disease NGS Panel
114 Genes:
ACTC1, ACVR2B, AKT3, ALMS1, ARL6, ARMC4, B9D1, B9D2, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BCOR, BRAF, C21orf59, CBL, CC2D2A, CCDC103, CCDC114, CCDC151, CCDC28B, CCDC39, CCDC40, CCDC65, CCNO, CEP290, CFAP53, CFC1, CHD7, CITED2, CPS1, CRELD1, CYR61, DNAAF1, DNAAF2, DNAAF3, DNAAF5, DNAH11, DNAH5, DNAH8, DNAI1, DNAI2, DNAL1, DRC1, DTNA, DYX1C1, ELN, FLNA, FOXF1, FOXH1, GATA4, GATA6, GDF1, GJA1, GPC3, HAND1, HRAS, INVS, JAG1, KIF7, KRAS, LEFTY2, MAP2K1, MAP2K2, MCIDAS, MED13L, MKKS, MKS1, MYH6, NEK8, NKX2-5, NKX2-6, NME8, NODAL, NOTCH1, NPHP3, NR2F2, NRAS, NSD1, NTRK3, OFD1, PIK3CA, PIK3R2, PITX2, PTPN11, RAF1, RAI1, RBM10, RIT1, RPGRIP1L, SEMA3E, SHOC2, SMAD6, SOS1, SPAG1, TAB2, TBX1, TBX20, TBX5, TCTN2, TLL1, TMEM216, TMEM231, TMEM67, TRIM32, TTC8, WDPCP, ZFPM2, ZIC3, ZMYND10
Dilated Cardiomyopathy NGS Panel
56 Genes:
ABCC9, ACTC1, ACTN2, ANKRD1, BAG3, CASQ2, CAV3, CHRM2, CRYAB, CSRP3, DES, DMD, DOLK, DSC2, DSG2, DSP, DTNA, EMD, GATAD1, GLA, JUP, LAMA4, LAMP2, LDB3, LMNA, MURC, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYOZ2, MYPN, NEBL, NEXN, PKP2, PLN, PRDM16, PRKAG2, PTPN11, RAF1, RBM20, RYR2, SCN5A, SGCD, TAZ, TCAP, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TRDN, TTN, TTR, VCL
Ehlers-Danlos Syndrome NGS Panel
04 Genes:
COL3A1, COL5A1, COL5A2, PLOD1
Hemiplegia/Stroke NGS Panel
10 Genes:
ATP1A2, ATP1A3, CACNA1A, COL4A1, COL4A2, NOTCH3, OTC, POLG, SCN1A, SLC2A1
Hypertrophic Cardiomyopathy NGS Panel
77 Genes:
A2ML1, ABCC9, ACTC1, ACTN2, ANKRD1, BAG3, BRAF, CALR3, CAV3, CBL, CRYAB, CSRP3, CTF1, DES, DMD, DSC2, DSG2, DSP, DTNA, ELAC2, EMD, FHL1, FKTN, GATA4, GATAD1, GLA, HRAS, ILK, JPH2, JUP, KRAS, LAMA4, LAMP2, LDB3, LMNA, MAP2K1, MAP2K2, MTO1, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOM1, MYOZ2, MYPN, NEBL, NEXN, NF1, NRAS, PDLIM3, PKP2, PLN, PRKAG2, PTPN11, RAF1, RASA1, RBM20, RIT1, RYR2, SCN5A, SGCD, SHOC2, SOS1, SPRED1, TAZ, TCAP, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, VCL
Jervell and Lange-Nielsen Syndrome NGS Panel
02 Genes:
KCNE1, KCNQ1
Left Ventricular Noncompaction NGS Panel
24 Genes:
ACTC1, ACTN2, DSP, DTNA, HCN4, LAMP2, LDB3, LMNA, MIB1, MYBPC3, MYH7, NEXN, PLN, PRDM16, RYR2, SCN5A, TAZ, TCAP, TNNI3, TNNT2, TPM1, TTN, VCL, YWHAE
Long QT Syndrome NGS Panel
16 Genes:
AKAP9, ANK2, CACNA1C, CALM1, CALM2, CALM3, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNJ5, KCNQ1, SCN4B, SCN5A, SNTA1
MarfanSyndrome and Thoracic Aortic Aneurysm and Dissection NGS Panel
22 Genes:
ACTA2, CBS, COL3A1, COL5A1, COL5A2, FBN1, FBN2, FLNA, MED12, MYH11, MYLK, NOTCH1, PLOD1, PRKG1, SKI, SLC2A10, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2
Noonan Syndrome NGS Panel
20 Genes:
A2ML1, ACTB, ACTG1, BRAF, CBL, HRAS, KAT6B, KRAS, LZTR1, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, RIT1, RRAS, SHOC2, SOS1, SOS2, SPRED1
Short QT NGS Panel
04 Genes:
CACNA1C, KCNH2, KCNJ2, KCNQ1
Sudden Death Syndrome NGS Panel
68 Genes:
AKAP9, ANK2, CACNA1C, CACNB2, CALR3, CASQ2, CAV3, CSRP3, CTF1, DES, DSC2, DSG2, DSP, DTNA, EYA4, FBN1, FBN2, FKTN, GJA5, GPD1L, JPH2, JUP, KCNA5, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNQ1, LAMP2, LDB3, LMNA, LRP6, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOZ2, NEXN, NPPA, PKP2, PLN, PRKAG2, PSEN1, PSEN2, RBM20, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SGCD, SLC25A4, SNTA1, TAZ, TCAP, TGFB3, TGFBR2, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, VCL