Cancers Panels

Genetic Testing for Cancer

Genetic testing can be useful for people with certain types of cancer that seem to run in their families. Predictive genetic testing is the type of testing used to look for inherited gene mutations that might put a person at higher risk of getting certain kinds of cancer. This type of testing might be advised:

  • For a person with a strong family history of certain types of cancer, to see if they carry a gene mutation that increases their risk. If they do have an inherited mutation, they might want to have tests to look for cancer early, or even take steps to lower their risk. An example is testing for changes in the BRCA1 and BRCA2 genes (which are known to increase the risk of breast cancer and some other cancers) in a woman whose mother and sister had breast cancer.
  • For a person already diagnosed with cancer, especially if there are other factors to suggest the cancer might have been caused by an inherited mutation (such as a strong family history or if the cancer was diagnosed at a young age). Testing might show if the person has a higher risk of some other cancers. It can also help other family members decide if they want to be tested for the mutation.
  • For family members of a person known to have an inherited gene mutation that increases cancer risk. Testing can help them know if they need tests to look for cancer early, or if they should take steps to try to lower their risk.

Cancer Panels

There are two types of panels available for cancer genetic testing:

  • Full Cancer Panel
  • Comprehensive Cancer Panel

Full Cancer Panel

The Full Cancer Panel helps you to determine your patients’ risks for hereditary cancer by assessing high and moderate penetrance genes. This panel allows for precision screening for the most common cancer predisposition syndromes through customizable and preset panels.

28 Genes:
APC, ATM, AXIN2, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, STK11, TP53 –

The Cancer Panel can be divided into the following panels:

Breast Cancer Focus Panel

14 Genes:
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MRE11, NBN, PALB2, PTEN, RAD50, STK11, TP53

Colorectal Cancer Focus Panel

16 Genes:
APC, AXIN2, BMPR1A, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53

Endometrial Cancer Focus Panel

10 Genes:
BRCA1, BRCA2, EPCAM, MLH1, MSH2, MSH6, PMS2, POLD1, PTEN, TP53

Ovarian Cancer Focus Panel

16 Genes:
ATM, BARD1, BRCA1, BRCA2, BRIP1, EPCAM, MLH1, MRE11, MSH2, MSH6, NBN, PMS2, RAD51C, RAD51D, STK11, TP53

Prostate Cancer Focus Panel

10 Genes:
BRCA1, BRCA2, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, PMS2, TP53

Comprehensive Cancer Panel

The Comprehensive Cancer Panel goes beyond typical hereditary cancer risk screening to include additional cancer predisposition genes. Fully customizable panels allow for maximum flexibility to meet your patients’ needs. These panels are a diagnostic tool for patients with non-specific, personal or family cancer histories.

122 Genes:
AIP, ALK, APC, ATM, ATR, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, BUB1B, CASR, CDC73, CDH1, CDK4, CDKN1B, CDKN1C, CDKN2A, CEBPA, CHEK2, CTC1, CYLD, DDB2, DICER1, DIS3L2, DKC1, EGLN1, EPCAM, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, EXT1, EXT2, EZH2, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FH, FLCN, GALNT12, GATA2, GPC3, GREM1, HOXB13, HRAS, KIF1B, KIT, LZTR1, MAX, MC1R, MEN1, MET, MITF, MLH1, MLH3, MRE11, MSH2, MSH6, MUTYH, NBN, NF1, NF2, NHP2, NOP10, PALB2, PDGFRA, PHOX2B, PMS2, POLD1, POLE, POLH, POT1, PRKAR1A, PRSS1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RB1, RECQL4, RET, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SLX4, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TERC, TERT, TINF2, TMEM127, TP53, TSC1, TSC2, TYR, VHL, WRAP53, WRN, WT1, XPA, XPC, XRCC2

The Comprehensive Cancer Panel can be divided into the following panels:

Breast Cancer Comprehensive Panel

18 Genes:
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MRE11, NBN, NF1, PALB2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, XRCC2

Colorectal Cancer Comprehensive Panel

19 Genes:
APC, AXIN2, BMPR1A, CHEK2, EPCAM, GALNT12, GREM1, MLH1, MLH3, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53

Endometrial Cancer Comprehensive Panel

10 Genes:
BRCA1, BRCA2, EPCAM, MLH1, MSH2, MSH6, PMS2, POLD1, PTEN, TP53

Fanconi Anemia Comprehensive Panel

17 Genes:
BRCA2, BRIP1, ERCC4, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, PALB2, RAD51C, SLX4, XRCC2

Gastric Cancer Comprehensive Panel

14 Genes:
APC, BMPR1A, CDH1, EPCAM, KIT, MLH1, MSH2, MSH6, NF1, PDGFRA, PMS2, SMAD4, STK11, TP53

Hematologic Malignancy Comprehensive Panel

16 Genes:
ATM, BLM, CEBPA, EPCAM, GATA2, HRAS, MLH1, MSH2, MSH6, NBN, NF1, PMS2, RUNX1, TERC, TERT, TP53

Melanoma Comprehensive Panel

09 Genes:
BAP1, BRCA2, CDK4, CDKN2A, CHEK2, MITF, PTEN, TP53, RB1

Nervous System / Brain Cancer Comprehensive Panel

26 Genes:
ALK, APC, ATM, DICER1, EPCAM, HRAS, LZTR1, MEN1, MLH1, MSH2, MSH6, NF1, NF2, PHOX2B, PMS2, PRKAR1A, PTCH1, PTEN, SMARCA4, SMARCB1, SMARCE1, SUFU, TP53, TSC1, TSC2, VHL

Ovarian Cancer Comprehensive Panel

17 Genes:
ATM, BARD1, BRCA1, BRCA2, BRIP1, EPCAM, MLH1, MRE11, MSH2, MSH6, NBN, PMS2, RAD51C, RAD51D, SMARCA4, STK11, TP53

Pancreatic Cancer Comprehensive Panel

22 Genes:
APC, ATM, BMPR1A, BRCA1, BRCA2, CDK4, CDKN2A, EPCAM, FANCC, MEN1, MLH1, MSH2, MSH6, NF1, PALB2, PMS2, SMAD4, STK11, TP53, TSC1, TSC2, VHL

Paraganglioma-Pheochromocytoma Comprehensive Panel

11 Genes:
FH, MAX, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

Prostate Cancer Comprehensive Panel

11 Genes:
BRCA1, BRCA2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PMS2, TP53

Renal / Urinary Cancer Comprehensive Panel

27 Genes:
BAP1, CDC73, CDKN1C, DICER1, DIS3L2, EPCAM, FH, FLCN, GPC3, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, SDHA, SDHB, SDHC, SDHD, SMARCA4, SMARCB1, TP53, TSC1, TSC2, VHL, WT1

Sarcoma Comprehensive Panel

26 Genes:
APC, BLM, CDKN1C, DICER1, EPCAM, FH, HRAS, KIT, MLH1, MSH2, MSH6, NBN, NF1, PDGFRA, PMS2, PRKAR1A, PTCH1, RB1, RECQL4, SDHA, SDHB, SDHC, SDHD, SUFU, TP53, WRN

Thyroid Cancer Comprehensive Panel

07 Genes:
APC, CHEK2, DICER1, PTEN, PRKAR1A, RET, TP53